ncRNA name | mmu-miR-15a |
ncRNA Category | miRNA |
Disease name | diabetic retinopathy (DR) |
Species | Mus musculus |
Tissues/Cell_line | retinas |
Methods | qRT-PCR, transfection, Western blot, immunostaining, luciferase reporter assay, in situ hybridizations (ISH) |
Expression pattern | down-regulated |
Functional description | We identified miR-15a as key regulator of both pro-inflammatory and pro-angiogenic pathways through direct binding and inhibition of the central enzyme in the sphingolipid metabolism, ASM, and the pro-angiogenic growth factor, VEGF-A. |
PubMed ID | 27531575 |
Year | 2016 |
Title | Dual Anti-Inflammatory and Anti-Angiogenic Action of miR-15a in Diabetic Retinopathy. |
Drug-related ncRNA | NO |
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